He has focused his research on wearable healthcare technologies, tele-medicine, functional soft biomaterials, stretchable bioelectronics, drug delivery systems, and smart manufacturing processes.

[6] Lee's research is focused on the development of wearable biomedical devices, with particular attention on the scalable production of stretchable sensors in quantities required for clinical testing, and ultimately widespread applications.

[7] Lee has made significant contribution towards the development of a skin sensor patch tailored for various human body parts in order to detect clinically important biosignals in real time.

Lee has teamed up with Laurent Couetil in Purdue Veterinary Medicine to develop a smart connected blanket for horse with asthma in order to monitor respiration rate continuously, or even overnight, from a distance.

Lee teamed up with Yanni Paulus in the University of Michigan Medicine to demonstrate the utility of the drug delivery system in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a noticeable side effect over current standard therapies.

[16] Moreover, he presented a review on the emerging trends and latest innovations of wearable glucose monitoring and implantable insulin delivery technologies for diabetes management with a focus on their advanced materials and construction.