The Chicago and Northwestern Depot is a former railway station in Wilmette, Illinois, which has been on the National Register of Historic Places since 1975.

The station served the Chicago and North Western Railway along what is now Metra's Union Pacific/North Line.

[1] The first railroad depot in Wilmette was built in 1870–71 for $700 by a group of landowners hoping to develop the area.

[1] The depot was designed in the Italianate style and was a brick building with a gabled roof and columns in front.

[2] In the 1890s, Wilmette's growing number of commuters wanted a new depot to be built on the inbound side of the tracks.