He received All-League, PrepStar All-West Region, first-team All-Area and helped his team claim back-to-back BVAL Mount Hamilton Division titles.

He committed to play college football for the University of Colorado Boulder, over offers from other Power 5 schools including Pac-12 opponents Utah and Washington State.

He also participated at Colorado's Pro Day along with Ahkello Witherspoon, Tedric Thompson, Sefo Liufau, and ten other teammates.

[11] Awuzie had private workouts and visits with the Dallas Cowboys, Philadelphia Eagles, Oakland Raiders, and Tennessee Titans.

[19] His selection is remembered by the intense speech that Drew Pearson gave amidst boos from the Eagles fans in attendance.

[21] Throughout training camp, Awuzie competed to be a starting cornerback against Jourdan Lewis, Marquez White, Nolan Carroll, Orlando Scandrick, and Anthony Brown.

Head coach Jason Garrett named Awuzie the fourth cornerback to begin the regular season, behind Nolan Carroll, Orlando Scandrick, and Anthony Brown.

On December 31, 2017, Awuzie recorded two solo tackles, deflected a pass, and made his first career interception during a 6–0 victory at the Eagles in Week 17.

Awuzie intercepted a pass by Eagles' quarterback Nick Foles, that was initially intended for wide receiver Alshon Jeffery, during the first quarter.

[27] He finished his rookie season in 2017 with 25 combined tackles (14 solo), seven pass deflections, one interception, and one forced fumble in ten games and six starts.

[30] Awuzie finished with season with 71 combined tackles (57 solo), 11 pass deflections, one interception, and one forced fumble in 15 games and 14 starts.

[34] In Week 1 against the Los Angeles Rams, Awuzie recorded his first interception of the season off pass thrown by Jared Goff during the 20–17 loss.

[40] Awuzie was named a starting cornerback alongside Trae Waynes, and would play in fourteen of seventeen games for the Bengals.

In Super Bowl LVI, Awuzie recorded his first career playoff interception off Rams' quarterback Matthew Stafford at the beginning of the third quarter.

Awuzie would injure his back during a practice session on October 5, 2023, leading to him sitting out the Bengals 34–20 win against the Arizona Cardinals in Week 5.

After an injury to Taylor-Britt during practice, Awuzie returned to the starting lineup ahead of Bengals' Week 11 game against the Pittsburgh Steelers.

He played the first three games of the season, recording four tackles, but suffered a groin injury early in Week 3's match against the Green Bay Packers.