He and Lano Hill anchored the Cass Technical defensive backfield that won back-to-back (2011 and 2012) Michigan High School Athletic Association Division 1 championships for coach Thomas Wilcher.

[7] As a junior, he started 13 games, posting 52 tackles (3.5 for loss), two interceptions and 20 passes defensed (ranked third in the Football Bowl Subdivision (FBS)).

[17] On January 10, 2017, it was reported that Lewis and teammates Chris Wormley and Ben Gedeon had all accepted their invitations to attend the 2017 Senior Bowl.

[18][19] On January 28, 2017, he recorded four combined tackles and displayed impressive coverage under Chicago Bears head coach John Fox as a part of the North team who lost 16–15 to the South.

[30] He was expected to compete with Orlando Scandrick, Chidobe Awuzie, Anthony Brown, and Nolan Carroll for a job as the starting cornerback, but suffered a hamstring injury during his first training camp practice and missed all of the preseason.

He went into the game after Carroll suffered a concussion and he recorded six solo tackles and intercepted the first pass of his career off of Broncos' quarterback Trevor Siemian in a 42–17 loss.

[32] The next week, he earned his first career start in place of Carroll and recorded six solo tackles and deflected a pass in a 28–17 win at the Arizona Cardinals.

During a Week 5 matchup against the Green Bay Packers, he made his second career start and collected seven combined tackles and a season-high three pass deflections in the Cowboys' 35–31 loss.

[34] Lewis gave up an 11-yard game-winning touchdown with 11 seconds left in the game to Davante Adams on a back shoulder fade thrown by Aaron Rodgers.

[39] In week 9 against the New York Giants, Lewis recovered a fumble forced by teammate Dorance Armstrong on Daniel Jones and returned it for a 63 yard touchdown in the 37–18 win.

[40] In week 14 against the Chicago Bears on Thursday Night Football, Lewis recorded a toe tapping interception off a pass thrown by Mitch Trubisky at the one yard line during the 31–24 loss.