A church at the site was erected in 1438 by Malatesta Novello after he defeated of the Ghibelline forces in the town.
The church we see today was restructured starting in 1761 and completed in 1791, using designs by Leandro Marconi the elder.
In 1465, Cardinal Bessarion donated to the church, his collection of choral books (for example, see antiphonary), some of which were transferred to the Biblioteca Malatestiana after the suppression of the convent.
[1] The facade is simple, made of brick, with an unusual semicircular round window, and a three arch portico.
The interior houses a 16th-century painting of the Madonna della Grazie and The Annunciation by Marcantonio Franceschini.