The Chiesa delle Anime Sante del Purgatorio or Church of the Holy Souls in Purgatory is a Roman Catholic church (or oratory) located on the Piazza Francesco Paolo Neglia and Via del Mercato in the town of Enna in Sicily, Italy.
In 1615–1616, permission to build a chapel or oratory dedicated for prayers of the (holy) Souls in Purgatory.
Construction proceeded under the patronage of the Confraternity of the Anime Sante del Purgatorio.
The portal in pink stone was sculpted with baroque decoration and a split tympanum.
The painter Guglielmo Borremans frescoed (1720–1723) the interior with depictions of the Glory with Madonna and Pope Urban VIII; Triumph of the Faith; and a Defeat of the Rebel Angels.