It is located on Via dei Cestari, near the corner with Corso Vittorio Emanuele II and across the street and diagonal from the Largo di Torre Argentina.

In 1597, the land was given by Pope Clement VIII to the Confraternita delle Ss.Stimmate; the construction of a new building was completed in 1714, from designs by Giovanni Battista Contini.

During the papacy of Clement XI, the facade was begun by Antonio Canevari, in a plan recalling Pietro da Cortona's style.

The first chapel to the right has a Flagellation by Marco Benefial, flanking paintings by Domenico Muratori with a cupola frescoed by Giovanni Odazzi.

The second chapel has a painting of the Virgin by Sebastiano Conca and a St Michael, a copy of the mosaic of St. Peters completed by Filippo Laurenti.