There was an early Christian church on the site, probably from the 6th century, also dedicated to San Giovenale.
[2] It stood next to another religious building dedicated to San Savino, the only record of which is contained in a fresco by Ugolino di Prete Ilario now in Orvieto Cathedral.
An inscription on the high altar (GUIDO ABAS MCLXX) indicates that by 1170 it belonged to the order of monks known as Ordine Guglielmino.
Refurbished and reconsecrated by Bishop Giuseppe Marsciano in 1739, it fell under the care of the church of Sant'Agostino until 1810 when it came under the Franciscans.
[2] The most notable work is the 15th-century Maestà known as the Madonna del Soccorso which was donated by the Ghezzi family in the 16th century.