The organization began with a single mobile medical unit funded by Simon and designed by Redlener's wife, Karen.

[1] More than 20 years later, the organization has 23 programs with more than 50 mobile medical units[2] and is the nation's leading provider of mobile-based health care for homeless and low-income children and their families.

[11] CHF's National Network serve children and families in Arkansas;[12] Austin, Texas;[13] Baton Rouge, Louisiana;[14] Chicago, Illinois;[15] Dallas, Texas;[16] Detroit, Michigan;[17] Harlem, New York;[18] Idaho;[19] Los Angeles, California;[20] Memphis, Tennessee;[21] Mississippi;[22] Mississippi Gulf Coast;[23] New Orleans;[24] New York City;[25] New Jersey;[26] Orlando, Florida;[27] Phoenix, Arizona;[28] San Francisco, California;[29] South Florida;[30] Southern Arizona;[31] Washington, D.C.;[32] and West Virginia.

[38] Since Hurricane Andrew, Children's Health Fund has activated a crisis response plan to help provide medical assistance to the victims of the disaster.

CHF initiated this plan again after the terror attacks of 9/11 providing support at ground zero in New York City;[39] after Hurricane Katrina ravaged the Gulf Coast in 2005;[40] and most recently after the BP Oil Spill.