In 2000, the museum moved to its current location on Broad Street in Richmond.

In 2010, the Children's Museum of Richmond became the first in the country to open a satellite location, at West Broad Village in Short Pump, located in the West End of Richmond.

The Short Pump & Fredricksburg locations closed in 2020 due to the COVID-19 pandemic.

The Short Pump Town Center location was replaced by Draftcade.

The museum is also home of Commonwealth Parenting and the Central Virginia Book Bank.