Chios mastic is certified by the Agricultural Products Certification and Supervision Organization as part of the Hellenic Ministry of Rural Development and Food.

Hippocrates used mastic for the prevention of digestive problems, colds and as a breath freshener.

Roman emperors used mastic along with honey, pepper, and egg in the spiced wine conditum paradoxum.

Digestive liqueurs, similar to Mastiha but made with grapes, were known as the Greek elixirs before the French Revolution.

Greek writer and journalist Zoe Rapti released a novel titled Έρωτας με Λικέρ Μαστίχα (Love with Mastic Liqueur) in 2013.