Chirality timeline

Chirality affects biochemical reactions, and the way a drug works depends on what kind of enantiomer it is.

Mismatching will make the drug less effective, which could be a matter of life and death, as happened with thalidomide in the 1960s.

[3][4] It has long been known that structural factors, particularly chirality and stereochemistry, have a big impact on pharmacological efficacy and pharmacokinetic behavior.

Since more than a century ago, pertinent information pertaining to chirality has been accumulating in numerous fields, in particular, physics, chemistry and biology, at an accelerated rate, giving rise to more comprehensive and in-depth reasoning, conceptions, and ideas.

[5][6][7][8] This page offers a chronology of significant contributions that have been made in the journey of chirality [1809 to 2021].