Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.

[1][2] It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure.

In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix).

Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

[4] The research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide.