The House of Chodkiewicz (Belarusian: Хадкевіч; Lithuanian: Chodkevičius) was one of the most influential noble families of Lithuanian-Ruthenian descent within the Polish–Lithuanian Commonwealth in the 16th and 17th century.

[1] Chodko Jurewicz, chamberlain to Grand Duke Vytenis, was probably the ancestor of the whole clan and gave it the name Chodkiewicz, meaning "son of Chodzko".

In 1572, Jan Hieronimowicz Chodkiewicz converted from Calvinism to Roman Catholicism with his two sons, which made them the first Polonized generation of the once Lithuanian-Ruthenian family.

Emperor Charles V granted them the title of Imperial Count.

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