6048263993ENSG00000115665ENSMUSG00000023945Q9GZV3Q2T9H3Q8BGY9NM_001305005NM_001305006NM_001305007NM_021815NM_022025NP_001291934NP_001291935NP_001291936NP_068587NP_001291936.1NP_071308The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene.

Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions.

SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons.

[7] The ChT seems to be a site of action of some β-neurotoxins found in snake venoms, which disrupt peripheral cholinergic transmission by interfering with presynaptic acetylcholine synthesis.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.