Delta hexatoxin Hv1 can result in fatality for primates, by downregulating the inactivation of voltage gated sodium ion channels (VGSCs) found in motor neurons.

[2][3] In 1997, Jamie I. Fletcher and his research associates introduced new nomenclature for classifying Australian funnel web spider toxins.

The amino acid sequence of delta hexatoxin Hv1 is:The tertiary structure of δ-ACTX-Hv1 contains a core β region that is made up of the residues Cys1–Cys8, Cys14–Val21, and Ser30–Ser33, with Tyr22–Gly29 protruding outwards.

The C-terminal end of the short β1 is held in place by a bifurcated hydrogen bond between the Cys8 amide proton and the carbonyl oxygens of the two residues preceding β strand 3 (Gln28 and Gly29).

[2] The peptides found in various venomous animals are capable of reducing inflammation, inactivating ion channels, and altering neurotransmitter production.

There are still many limitations in this research due to a lack of sufficient natural resources, however using recombinant DNA is used a way to mitigate this issue by promoting heterologous protein expression and peptide chemical synthesis.