Agos played Apollo 11 astronaut Buzz Aldrin in the Apple TV+ original science fiction space drama series For All Mankind, ASA Steve Kot in Chicago PD on NBC, Eliot McGantry in Boss on Starz, and has had numerous single-episode appearances on television shows such as Grey's Anatomy, House of Cards, and Sirens.

[4] Agos began studying voice over acting while attending DePaul University in Chicago as a distraction from medical school entrance exams.

[5] In addition to working in voice over, he began appearing in commercials, corporate projects and print ads before being cast in minor roles in television shows such as The Beast, Cooper and Stone, The Chicago Code, Grey's Anatomy, House of Cards, and Sirens.

In 2014 he was cast as ASA Steve Kot in Chicago PD, a role he played for nearly three seasons.

Agos gained media attention after being cast as astronaut Buzz Aldrin in For All Mankind, part of the original slate of four shows which launched the Apple TV+ streaming platform.