In Australia, he appeared on the lifestyle program The Living Room, and alongside Julia Morris was the presenter of the local version of I'm a Celebrity...Get Me Out of Here!.

Brown was born and grew up in the suburbs of Merewether Heights, Newcastle, New South Wales, where his father was a local vet.

[7] Brown's first television presenting role as a vet was on Harry's Practice in 2003, for which he was nominated for a "Most Popular New Talent" Logie Award.

[8][9] In 2008, he began writing a column called "Pet Page" in Woman's Day magazine and was interviewed on radio stations Triple M and Vega FM.

Since 28 September 2013, the show is seen on Saturday mornings in the United States on the CBS network, under the title of Dr. Chris: Pet Vet.

In 2012, Brown began co-hosting Network Ten's lifestyle show The Living Room with Amanda Keller, Miguel Maestre and Barry Du Bois.

[18][19] In October 2023, Daryl Somers announced that he would be stepping back from hosting Seven Network's Dancing with the Stars Australia, and that Brown would be taking over his duties for the show's 21st season set to premiere in 2024.

"[23] Brown owns the website drool.pet, where he shares pet tips, insights and sells a range of treats, washes and care products.