He left Nova to join Dillard High School in Fort Lauderdale, Florida in 2000.

Gamble played cornerback, wide receiver, and kick returner at Ohio State.

[citation needed] Gamble majored in sports and leisure studies while at Ohio State.

[3] Head coach John Fox named Gamble the starting cornerback to begin the regular season, alongside Ricky Manning.

[4] In 2004, Chris became the first rookie defensive player in Carolina Panthers history to start all 16 games, and earned Pro Football Weekly All-Rookie honors after establishing a Panthers rookie record with six interceptions, placing him in third in the NFL in interceptions.