[2][3] Harris was named All-State in basketball and football as defensive back senior year (2006) after helping the Spartans to the district title.

[4] Harris helped lead Bixby High School to second place in the 2005 state football championship, coached by Pat McGrew.

[10][11] Throughout training camp, Harris competed for a roster spot against Perrish Cox, Chevis Jackson, Darcel McBath, Kyle McCarthy, and Syd'Quan Thompson.

In Week 4, Harris emerged as a possible future top cornerback prospect after replacing an ineffective Cassius Vaughn and making four combined tackles during a 49–23 loss at the Green Bay Packers.

[20] Harris finished his rookie season with a career-high 72 combined tackles (62 solo), six pass deflections, and one interception in 16 games and four starts.

On January 8, 2012, he played in his first career playoff game and recorded five combined tackles in a 29–23 overtime victory over the Pittsburgh Steelers in the AFC Wild Card Round.

[24] The following week, Harris started his first career playoff game and made eight combined tackles as the Broncos lost 45–10 to the New England Patriots in the AFC Divisional Round.

[25] The Broncos signed free agent Tracy Porter and hired Jack Del Rio as their new defensive coordinator.

[citation needed] On September 30, 2012, Harris recorded three solo tackles and made his first career sack on Carson Palmer during a 37–6 defeat over the Oakland Raiders.

[27] Prior to Week 6, Harris was named the starting outside cornerback, along with Champ Bailey, after Tracy Porter was inactive due to seizure-like symptoms.

[28] On October 15, 2012, Harris made four solo tackles, two pass deflections, a touchdown, and intercepted San Diego Chargers' quarterback Philip Rivers twice in a 35–24 victory.

[33] On January 12, 2013, Harris started and recorded three solo tackles and four pass deflections in the Broncos' 38–35 2OT loss to the Baltimore Ravens in the AFC Divisional Round.

[34] Harris returned from his stellar season to enter training camp behind newly acquired free agent Dominique Rodgers-Cromartie on the depth chart.

[35] He started the Denver Broncos' season-opener against Baltimore and recorded three solo tackles, a pass deflection, and intercepted Joe Flacco during their 49–27 victory on Thursday Night Football.

[40] On January 12, 2014, Harris recorded two solo tackles and deflected a pass during a 24–17 victory over the San Diego Chargers in the AFC Divisional Round.

[47] They signed free agent and his former Kansas teammate Aqib Talib and opted not to re-sign longtime veteran Champ Bailey.

[48] Head coach John Fox named Harris and Talib the starting cornerbacks to begin the 2014 regular season against the Colts.

[62] Harris finished the regular season with 58 combined tackles (49 solo), six pass deflections, two interceptions, two forced fumbles, and a touchdown in 16 games and 16 starts.

[64][65] On February 7, 2016, Harris recorded five solo tackles and a sack as the Broncos defeated the Carolina Panthers 24–10 to win Super Bowl 50.

On September 17, 2017, Harris recorded a season-high six solo tackles, two pass deflections, and an interception off quarterback Dak Prescott during a 42–17 victory over the Dallas Cowboys.

[88] Harris was retained as the Broncos’ starting left cornerback for the 2019 season under new head coach Vic Fangio and defensive coordinator Ed Donatell.

In Week 6 against the Tennessee Titans, Harris recorded his first and only interception of the season off Marcus Mariota and forced a fumble in the 16–0 win.

[95] In Week 15 against the Las Vegas Raiders, Harris recorded his first interception as a Charger off a pass thrown by Marcus Mariota and made a 51 yard return during the 30–27 overtime win.

[101] Harris finished the 2022 season with one sack, 29 total tackles, three passes defended, and one forced fumble in ten games and four starts.

[102] Harris became a free agent following the season, and stated that he would wait to sign a deal with the hopes of catching on with a Super Bowl contender.