He also recorded 45 tackles, eight pass breakups and one interception as a cornerback, and helped Dominguez to a CIF Southern Section Division III title with a 41–14 victory over Sherman Oaks Notre Dame High School in the championship game.

[16] He made it to the finals of the state meet in the 110-meter hurdles, placing third with a time of 13.99 seconds, and also finished sixth in the long jump, with a mark of 7.25 meters.

[2][28] On January 29, 2011, Sherman played in the 2011 Senior Bowl and deflected two passes as part of Marvin Lewis' North team that lost 24–10 to the South.

At the conclusion of the pre-draft process, Sherman was projected to be selected anywhere from the fourth to sixth rounds by the majority of NFL draft experts and scouts.

[41][42] Throughout training camp, Sherman competed to be a starting cornerback against Walter Thurmond, Kelly Jennings, Byron Maxwell, Brandon Browner, and Kennard Cox.

[43] Head coach Pete Carroll named Sherman the fourth cornerback on the depth chart to begin the regular season, behind Marcus Trufant, Brandon Browner, and Walter Thurmond.

In Week 4, Sherman made his first career solo tackle during a 13-yard punt return by wide receiver Eric Weems as the Seahawks lost 30–28 to the Atlanta Falcons.

[45] On October 30, 2011, Sherman earned his first career start after Marcus Trufant and Walter Thurmond were both placed on injured reserve for the remainder of the season.

Sherman intercepted a pass by Cardinals' quarterback John Skelton, that was initially intended for wide receiver Andre Roberts, and returned it for a 33-yard gain in the fourth quarter.

[50] Sherman finished his rookie season in 2011 with 55 combined tackles (47 solo), 14 pass deflections, four interceptions, and a forced fumble in 16 games and ten starts.

[61] On November 25, 2012, it was reported that Sherman and teammate Brandon Browner were both facing four-game suspensions after they were accused of taking Adderall which violated the league's policy against performance-enhancing substances.

Sherman intercepted a pass by quarterback John Skelton, that was originally intended for wide receiver Larry Fitzgerald, and returned it for a 19-yard touchdown in the second quarter.

[69] On January 6, 2013, Sherman started in his first career playoff game as the Seahawks defeated the Washington Redskins 24–14 in the NFC Wild Card Round.

[73][74] In Week 4, Sherman made four solo tackles, two pass deflections, and returned an interception for a touchdown as the Seahawks' defeated the Houston Texans 23–20 in a comeback victory.

Sherman intercepted a pass by quarterback Matt Schaub, that was intended for tight end Owen Daniels, and returned it for a 58-yard touchdown in the fourth quarter despite losing his shoe to tie the game 20–20 which sent it into overtime.

[86] On January 19, 2014, Sherman made two combined tackles and a pass deflection as the Seahawks defeated the San Francisco 49ers 23–17 in the NFC Championship Game.

He played a critical role and deflected a pass by quarterback Colin Kaepernick, that was intended for Michael Crabtree, which was caught by teammate Malcolm Smith to seal the Seahawks' 23–17 victory.

He left the game with a high ankle sprain and spent majority of the fourth quarter on the sidelines with a walking boot and crutches in Seattle’s dominant 43–8 victory over Denver Broncos, the league's best offense.

[104] On January 10, 2015, Sherman recorded three combined tackles, two pass deflections, and intercepted Cam Newton during the Seahawks' 31–17 victory against the Carolina Panthers in the NFC Divisional Round.

[105] The following week, Sherman made four combined tackles, a pass deflection, and intercepted Aaron Rodgers during a 28–22 overtime victory against the Green Bay Packers in the NFC Championship.

[108] Following the conclusion of the NFL season, the Pro Football Writers Association selected Sherman to win the PFWA Good Guy Award for his willingness to work with and provide insightful information to the media.

[140] In Week 1 against the Tampa Bay Buccaneers, Sherman intercepted a pass thrown by Jameis Winston and returned it 37 yards for a touchdown in the 31–17 win.

[144] In the Divisional Round of the playoffs against the Minnesota Vikings, Sherman intercepted a pass thrown by Kirk Cousins and returned it for 13 yards during the 27–10 win.

[145] In the NFC Championship against the Green Bay Packers, Sherman recorded two tackles and picked off Aaron Rodgers in the final two minutes of the game, which sealed a 37–20 win and a trip to Super Bowl LIV.

[157] He was activated on December 10 in time for the team's Week 14 game against the Buffalo Bills, where Sherman recorded his only interception of the season off a pass thrown by Josh Allen in the Buccaneers' 33–27 overtime win.

[168] Sherman's outspoken personality, tendency for making big plays, and his frequent trash-talk made him one of the NFL's best-known players of his era.

[177] On July 14, 2021, Sherman was arrested in Redmond, Washington and initially booked on suspicion of burglary domestic violence, a felony charge which was later dropped.

[178] Sherman's charges were later updated to include five misdemeanors: second-degree criminal trespass and malicious mischief in the third degree, both with a domestic violence designation, as well as resisting arrest, driving while under the influence, and reckless endangerment of roadway workers.

[183] The NFL reportedly activated its emergency Domestic Violence protocols and opened an investigation into the matter to determine appropriate discipline for Sherman on July 14, 2021.

[184][185] In a March 2022 plea bargain, Sherman pleaded guilty to first-degree negligent driving, second-degree criminal trespass, and speeding in a roadway construction zone.