He starred in Unstoppable (2010), Rise of the Guardians (2012), Hell or High Water (2016), The Contractor, Don't Worry Darling (both 2022), and Dungeons & Dragons: Honor Among Thieves (2023).

[3][4] His father, Robert Pine, is an actor who co-starred on CHiPs as Sergeant Joseph Getraer, while his mother, Gwynne Gilford, is a former actress who became a psychotherapist.

His maternal grandfather, Max M. Gilford,[7] who came from a Russian Jewish family,[8] was an attorney who was elected president of the Hollywood Bar Association.

[26][27] In 2007, he starred opposite Scott Wolf in the Los Angeles production of Neil LaBute's play Fat Pig, winning positive reviews for his depiction of a competitive alpha-male friend.

[31] That same month, he made a brief appearance promoting the film on Saturday Night Live with co-stars Zachary Quinto and Leonard Nimoy.

[41] Pine co-starred with Elizabeth Banks, Olivia Wilde, and Michelle Pfeiffer in the family drama People Like Us, which was filmed in early 2011 and released in June 2012.

[43] In 2009, Pine entered talks to play CIA analyst Jack Ryan in a reboot of Tom Clancy's novels.

[49] In May 2015, Pine was confirmed to play one of the Howard brothers along with Ben Foster in Hell or High Water (originally called Comancheria).

[53] Also in July 2016, he received a Primetime Emmy Award nomination for Outstanding Character Voice-Over Performance for his work on the series SuperMansion.

[54] That same year, Pine was featured on singer Barbra Streisand's album Encore: Movie Partners Sing Broadway, in which the two duetted on a medley of the songs "I'll Be Seeing You" and "I've Grown Accustomed to Her Face".

[61] In 2018, Pine played Dr. Alexander Murry in the fantasy film A Wrinkle in Time, based on the novel of the same name,[62][63] and starred as Robert the Bruce in Outlaw King.

[68] In July 2017, the US cable network TNT announced Pine would play the role of Jay Singletary in a six-episode television drama, One Day She'll Darken.

[70] In 2020, Pine appeared as Westley in Home Movie: The Princess Bride for Quibi to raise money for World Central Kitchen.

[76] Pine executive produced and starred in the 2022 action-thriller The Contractor,[77][78] and appeared in Don't Worry Darling, a psychological thriller film directed by Olivia Wilde, released in September 2022.

[79] In December 2020, it was announced that Pine will star in Dungeons & Dragons: Honor Among Thieves, a film based on the role-playing game of the same name.

The film is reportedly a comedic mystery in the vein of Chinatown (1974) and was co-produced by Patty Jenkins and co-starred Annette Bening, Danny DeVito and Ariana DeBose.

"[82] The Hollywood Reporter noted, "Given its world premiere at Toronto, where it arrived looking for distribution, this TIFF stiff will likely have a tough time finding a home based on the tepid response from the customarily effusive festival audience".

[86][87] On March 1, 2014, while filming Z for Zachariah in New Zealand, Pine was arrested by police near Methven after failing to pass a routine roadside breath alcohol test.

[94] During the 2016 presidential campaign, Pine along with his fellow Star Trek co-stars J. J. Abrams, John Cho, Simon Pegg, Zachary Quinto, Zoe Saldana, Karl Urban, George Takei, Justin Lin, Bryan Fuller, and Adam Nimoy, endorsed a movement called Trek Against Trump.