Klotz published in various literary journals, among them Acta Litteraria, and introduced his students to Italian poetry as of Torquato Tasso.
Klotz' strength was his ability to cover a wide range of topics and his aesthetic as well as enjoyable style, both in Latin and German.
Klotz' work Ueber den Nutzen und Gebrauch der alten geschnittenen Steine (1768) criticizing Lessing's Laokoon, had brought forth that poet's response in the Briefe antiquarischen Inhalts (1768–69).
His disputes were carried on in Acta Literaria and Deutschen Bibliothek der schönen Wissenschaften (1767–72), both of which he edited along with Neuen Hallischen gelehrten Zeitungen.
Other works were Vindiciae Horatianae (1764), Lectiones Venusinae (1771), and an edition of Marco Girolamo Vida's De Arte Poetica (1776).