A persistent critic of disinformation activities, Esguerra was the former anchor and managing editor of the political talk program After the Fact on ABS-CBN News Channel (ANC), launched in May 2020.
[2] On 30 March 2022, Esguerra announced via Twitter the termination of After the Fact, citing the "prevailing political climate" as the reason for ending the program.
In 2020, ABS-CBN's franchise was not renewed by the Rodrigo Duterte government-leaning supermajority in the Philippine Congress, which forced the main terrestrial channel to go off-air.
He regularly sits down with key figures like former Presidential Adviser Ronald Llamas, former Senator Antonio Trillanes, economist Cielo Magno, and others from the political and academic world.
His interviews stand out for their depth and thoughtfulness, with Esguerra’s style often praised for bringing out meaningful, candid responses from his guests.