[1] On television, he has had guest starring roles on Brothers & Sisters, Moonlight, Family Time, Beauty and the Beast, Instant Mom, Mistresses and Born Again Virgin.
[2] Keyes made an appearance on the CW hit show “Supernatural”, playing the character Michael the Archangel.
Keyes has appeared in several films and made-for-television movies, include leading roles in Perfect Combination (2010), Lord, All Men Can't Be Dogs (2011) alongside Vivica A.
In 2016, Keyes was cast as male lead alongside Vanessa Bell Calloway, Gloria Reuben, Jasmine Burke and Clifton Powell in the Bounce TV prime time soap opera, Saints & Sinners.
His novel Ladies Night was released in 2015 and was later adapted into a 2021 BET+ television drama crime series All The Queen's Men, written and produced by Keyes and Tyler Perry Studios.