In 2014, family medicine physician Janice E. Nevin, M.D., MPH, became president and CEO of the health system.

[6] In 2017 it was reported that the Health Care system was ranked as the 22nd leading hospital and the 11th on the East Coast in terms of admissions.

It is home to Delaware's only Level 3 neonatal intensive care unit and the state's largest maternity center, where more than 7,100 newborns are delivered each year.

In 2018, the hospital opened Delaware's first epilepsy monitoring unit, where doctors attempt to induce a seizure to make a proper diagnosis.

[9] During the COVID-19 pandemic, in mid-December 2020, Delaware resident president-elect Joe Biden received his first vaccination at Christiana Hospital on live TV[10] and returned in mid-January 2021 for his second shot.

Its campus is also home to the Roxana Cannon Arsht Surgicenter, Wilmington Hospital Health Center, an HIV program and the First State School,[12] a private/public partnership that provides in-school education for children with serious illnesses that would otherwise render them homebound.

[13] Since 2019, Wilmington Hospital houses the Center for Hope and Healing which strives to provide care for individuals struggling with mental illness, medical conditions, and social health issues.

[17] In 2019, after a compliance review, the emergency department earned Advanced Disease-Specific Care Certification as an Acute Stroke Ready Hospital from The Joint Commission.

[20] It will provide care in various specialties such as oncology, gastroenterology and audiology, in addition to its imaging and laboratories technology.