She lost her seat in 2007, but in August 2012, the Samaras government appointed her Secretary-General of the Decentralized Administration of the Aegean, a position she gave up in April 2014 to contest the 2014 regional election for the North Aegean.
With her electoral list named "We, in the Aegean", supported by Nea Dimokratia, Kalogirou finished first winning 31.51% of the vote.
[1] In the second round, she won 53.01%, thereby defeating the incumbent Nasos Giakalis [el], who was elected in 2010 for the PASOK party but this time ran on an independent ticket.
Following a complaint, the Administrative Court of Piraeus in August annulled the electoral result, on the grounds that Kalogirou had held a political office within the last 18 months of the election.
On 2 October, the Council of State however overturned this decision, so she could assume her new office the same day.