Eastern Macedonia and Thrace (/ˌmæsəˈdoʊniə/ MASS-ə-DOH-nee-ə; Greek: Ανατολική Μακεδονία και Θράκη, romanized: Anatolikí Makedonía ke Thráki, [anatoliˈci maceðoˈnia ce ˈθraci]) is one of the thirteen administrative regions of Greece.

With the 2010 Kallikratis plan, its powers and authority were redefined and extended, with the preexisting region in many respects inheriting status and weight of the five now abolished prefectures, Drama, Evros, Kavala, Rhodope and Xanthi.

In this special case, the region of Eastern Macedonia and Thrace also succeeds the intermediate structure of the two super-prefectures of Drama-Kavala-Xanthi and of Rhodope-Evros into which the five prefectures had been grouped since 1994.

The political office of regional governor was also created by the Kallikratis reform and may be considered the successor of the former prefects.

Unlike the Muslims of Macedonia, Epirus, and elsewhere in northern Greece, they were exempted from the Greek-Turkish population exchange following the 1923 Treaty of Lausanne.