She married her first husband, Count Charles Louis of Nassau-Saarbrücken, on 22 April 1713 in Saarbrücken: She closed her second marriage on 17 October 1728 in Saarbrücken with Landgrave Frederick III of Hesse-Homburg.

This marriage came into existence after mediation by Frederick's brother, Landgrave Ernest Louis of Hesse-Darmstadt.

An imperial debit commission had found only two silver spoons at the court.

Frederick III had raised concerns and proposed to inform his bride-to-be, who demanded a proper dower, about his financial situation.

From her first marriage, Christiane Charlotte had two sons, who, however, both died in infancy: