[5] In 2003, Seeger recovered a $2 million verdict following a six-week jury trial against drug maker Pfizer on behalf of a Brooklyn resident who sustained livery injury following her use of the diabetes medication Rezulin.

[7] In 2007, Seeger won a $47.5 million verdict on behalf of an individual plaintiff, Idaho postal worker Frederick "Mike" Humeston, who suffered a heart attack after taking the drug.

The drywall emitted noxious fumes which caused headaches and rashes, made breathing difficult,[11][12] and damaged household wiring and plumbing.

[13] Seeger secured the initial trial victories against the companies that produced and distributed the drywall, paving the way for a subsequent $1 billion nationwide settlement.

[16] Since 2012, Seeger served as lead counsel representing retired NFL players in a suit brought against the league for hiding the dangers of concussion injuries.

He negotiated a settlement in which the NFL agreed to pay an uncapped amount, estimated to be over $1.5 billion,[17] to address the medical costs of over 20,000 former players who suffered traumatic brain injuries during their professional careers.

[19] In 2016, Seeger was appointed to the Plaintiffs’ Steering Committee in the “clean diesel” litigation against German automaker Volkswagen in connection to the company's project to game the emissions tests on their cars.

The litigation includes over 250,000 veterans suffering from hearing loss and tinnitus after using earplugs 3M sold to the U.S. Department of Defense, which the suit claims the company knew to be faulty.

[26] Since 2019, Seeger has served as interim co-lead counsel for a proposed "negotiation class" of local governments in the pursuit of a nationwide settlement against drug companies in multidistrict opioid litigation.