Clayton was educated at Harrow School and Heidelberg and graduated from University College, Liverpool with a PhD in chemistry in 1896.
[1] On graduation he obtained a post with the United Alkali Company of Widnes.
[2] At the 1922 general election he succeeded in regaining the Widnes constituency for the Conservative party.
[4] At the 1931 general election he returned to parliament as MP for the Wirral Division of Cheshire.
[7][8] Clayton married Mabel Valentine Grainger of Perth in 1896, and made his home at Kilry Lodge, Alyth, Perthshire, where he died in 1945 aged seventy-six.