The station was built by the Interborough Rapid Transit Company (IRT) as part of the Dual Contracts with New York City, and opened on July 1, 1918.

[6] It was predicted that the subway extension would lead to the growth of the Lower West Side, and to neighborhoods such as Chelsea and Greenwich Village.

[10][12] The new "H" system was implemented on August 1, 1918, joining the two halves of the Broadway–Seventh Avenue Line and sending all West Side trains south from Times Square.

In 2023, a bill was introduced in the New York State Legislature to rename the station after the nearby Stonewall National Monument.

The station is served by the 1 at all times[23] and by the 2 during late nights;[24] the center express tracks are used by the 2 and 3 trains during daytime hours.

[26] Both platforms have the standard IRT trim line and mosaic name tablets reading "CHRISTOPHER ST. SHERIDAN SQ."

The columns are painted dark green with every other one having the standard black station name plate with white lettering.

The station features a site specific artwork, entitled Greenwich Village Murals, created in 1994 by Lower East Side artist Lee Brozgol and the students of Public School 41.

It features twelve mosaic frame panels on the platform walls depicting the history of Greenwich Village.