After demolition during the bombing of Mainz in World War II the church was reconstructed between 1952 and 1954.
In the predominantly Catholic Mainz of 1802, only some hundred Protestants could be traced at the end of the Ancien Régime.
The extension of the old city borders by the new expanded town Mainz-Neustadt during the last trimester of the 19th century opened the opportunity to demonstrate the self-confidence of the Protestant community by erecting a new church building.
Along with the Kaiserstraße, a new twin lined three-lane boulevard, the church was erected by Eduard Kreyßig, the master builder of Mainz, in Renaissance Revival style.
Traditionally the opening mass services of the University of Mainz at the beginning of the academic term take place here.