They often lead to an increased tendency to develop certain types of malignancies.
[1] The following chromosome instability syndromes are known: Chromosome instability syndromes include several inherited neurodegenerative diseases that are due to mutations in genes that encode enzymes necessary for DNA repair.
This complex functions in homologous recombination and repair of DNA double-strand breaks.
Inherited mutations in MCM8 and MCM9 can cause a chromosomal instability syndrome characterized by ovarian failure.
[2][3] The germline MCM8-MCM9 protein complex is most likely required for the resolution of double-strand breaks that occur during homologous recombination in the pachytene stage of meiosis I.