[2] The longest tributaries of the Chrudimka are:[3] The most notable settlement on the river and the final destination before it enters the Elbe is the city of Pardubice.

The river flows through the municipal territories of Krouna, Kameničky, Hamry, Hlinsko, Vítanov, Vysočina, Trhová Kamenice, Horní Bradlo, Seč, Bojanov, Libkov, České Lhotice, Svídnice, Slatiňany, Chrudim, Tuněchody, Úhřetice, Úhřetická Lhota and Pardubice.

Its purpose is primarily flood protection, but it is also used for recreation, hydropower generation and water retention in the dry season.

[1] Before the Křižanovice II Reservoir there is Práčov, the largest hydroelectric power station in the Pardubice Region.

[4] Along the course of the river from its source to Chrudim there is an educational trail called Krajem Chrudimky ("through Chrudimka's region"), which is 82 km (51 mi) long.