With the start of enrolment of female students by Chung Cheng High School in 1947, student population increased significantly throughout the post war years, and the initial premise of the school at River Valley became increasingly overcrowded.

Chung Cheng High (Branch) was relocated to 339 Guillemard Road, while the original premises at 60 Kim Yam Rd becoming part of the extension for the campus of Nan Chiau Girls' High School.

In the late 1980s, there was an urgent need to upgrade the school facilities and to move to a spacious location.

Chung Cheng High School (Yishun) offers 20 Co-Curricular Activities (or CCA).

Every student in Chung Cheng High School (Yishun) is expected to participate in a CCA from one of the four domains, namely: Clubs & Societies, Physical Sports, Uniformed Groups and Visual & Performing Arts.