The building was designed by Fra Giuseppe Nuvolo, and built initially by Silvestro Cordella.
In 1837, it underwent restoration by Francesco de Cesare, and an oval dome was added in the early 19th century.
The interior has bas-reliefs by Vincenzo Annibale depicting a story from the Life of San Carlo and a Christ.
A partially damaged, but much revered, crucifix (1599) by Michelangelo Naccherino, once stood in the Basilica dello Spirito Santo.
[2] Giuseppe Mancinelli painted Carlo Borromeo providing the Viaticum to victims of the Plague.