In the 17th century, small groups of Greek merchants and Serbs who had fled Turkish rule, appeared in Warsaw (and in other major cities in Poland).

The church featured a three-row iconostasis, into which icons were placed which had been imported from Greece or bought from French soldiers retreating from Russia.

Only in 1828 did the church receive a permanent pastor, Father Theophilus Nowicki, who was sent from Kremenets, and at the time the parish only had 62 followers.

From 24 to 31 August it was defended by troops of the AK "Gustav" battalion, including the sanitary patrol "Ewa–Maria", which was unable to control the fires, so the church was evacuated.

During the bombing of the house a vicar from the parish, Father Jerzy Łotocki, his wife, son, and mother-in-law, all died.

The front tenement was rebuilt, and the property was earmarked for residential purposes, while the ruins of the chapel in the courtyard were levelled.

The ground floor of the church was decorated again with new iconostasis made in Bielsk Podlaski by students from the Postgraduate Studies of Iconography (Policealne Studium Ikonograficzne) post-secondary school.

A surviving previous copy of the Pochayiv Mother of God icon is currently located in the new chapel, along with a silver Gospel Book, which had been stored in the Cathedral of St. Mary Magdalene, after it was found after the war in the rubble of the destroyed church.