[1] Railroad construction in the late 1840s and early 1850s brought scores of Irish immigrant laborers to the city, considerably boosting the congregation's numbers.
[3] Father Abram Joseph Ryan (1836–1886), the Poet-Priest of the Confederacy, was once a priest at this parish.
The brick church was designed by Joseph Baumann, who along with George Franklin Barber was one of Knoxville's first major professional architects.
The church remains a Roman Catholic parish in the downtown portion of the city.
However, Sacred Heart Cathedral in the west Knoxville community of Bearden is the seat of the Catholic Bishop.