The church was built at the behest of two priests, Pietro Micichero and Domenico Verrucca, who had founded a congregation of secular canons.

From 1441 it was officiated by the Canonici di San Giorgio in Alga, popularly called "Celestini", who remained there until 1668 when the congregation was dissolved by Pope Clement IX.

[1] It was then entrusted to secular clergy, becoming a branch of San Martino d'Albaro.

In the 1940s the church underwent a major restoration, which involved almost a total renovation of the building.

This reconstruction virtually erased the various reconstructions of the Baroque era to bring the building, at least in its essential structure, back to its original fifteenth-century form, although the restoration was undertaken in an interpretive and not scientifically rigorous fashion.