[1] In a dedication ceremony held on August 29, 2014, the interchange was renamed in honor of former Chicago mayor Jane M. Byrne (1979–1983).

[citation needed] The tracks of the Chicago Transit Authority Blue Line 'L' train pass directly underneath the center of the interchange, running in an east–west direction, as they transition from surface operation in the median of the Eisenhower Expressway, to a subway to the east of the Interchange.

[2] The market's radio and television traffic reporting services immediately instituted the interchange's new name, although many went with a dual reference of the "Jane Byrne–Circle Interchange" during a transition period until the services updated their maps and road signage was changed to reflect the new name, to avert confusion.

In August 2012, the Illinois Department of Transportation (IDOT) began the planning and design phases for the potential rehabilitation of this interchange.

[12][13] On April 3, 2013, the Chicago Tribune featured a front-page article on the estimated $420 million project, which was slated to take four years.

[16] The interchange, as well as a series of overpasses surrounding it, would receive a complete overhaul, including the addition of a flyover ramp from northbound I-90/I-94 to westbound I-290.

The northwest flyover of the Jane Byrne Interchange opened on December 4, 2016, after which the old ramp was closed and demolished.

[19] Delays and increasing costs led to a final completion date of December 16, 2022, at which time all lanes and ramps were opened to motorists.