The Circuito Sur de Oriente (CSO), meaning "Southern Circuit of the Orient", is a west-east highway connecting Bayamo to Santiago de Cuba, through Manzanillo, Niquero and the southern coastal side of eastern Cuba, below the Sierra Maestra mountain range.

The CSO, whose endpoints cross the Carretera Central, starts in Bayamo, capital of Granma Province, and ends in Santiago, the second Cuban city and capital of Santiago de Cuba Province.

It is divided into a pair of Carretera branches: The table below shows the route of the Circuito Sur de Oriente.

[1] Note: Provincial seats are shown in bold; the names shown under brackets in the section "Municipality" indicate the municipal seats.

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