It is located in the coastal region of the province, bordering the Gulf of Guacanayabo.

During Cuban Revolution, Niquero was the site of the landing of Granma, a yacht boarded by 82 members of the 26th of July Movement, including Fidel Castro, Raúl Castro, Che Guevara and Camilo Cienfuegos.

On 2 December 1956 the yacht, departed from Tuxpan, in Mexico, landed in Los Cayuelos near the beach Playa Las Coloradas, few km in south of the town.

The municipality is divided into the barrios of Belic, Guanito, Jagua, La Marea, El Plátano, Sevilla Abajo, Cabo Cruz, Hondón, Marea de Belic, Alegría de Pío, Estacadero, La Ricardo, etc.

The town is crossed by the state highway "Circuito Sur de Oriente" (CSO).