Cape Cruz, (Spanish: Cabo Cruz), is a cape that forms the western extremity of the Granma Province in southern Cuba.

It extends into the Caribbean Sea and marks the eastern border of the Gulf of Guacanayabo.

[1] Cape Cruz is located in the municipality of Niquero and is part of the Desembarco del Granma National Park.

The southernmost tip of Cape Cruz is marked by Faro Vargas, a nineteenth-century lighthouse with a height of 32 metres (105 ft).

The cape is the endpoint of the Niquero branch of the "Circuito Sur de Oriente" (CSO) highway.