Cissus cornifolia is a species of flowering plant in the Vitaceae family.

Growing from a large tuberous rootstock and found up to 2000m, in open woodland and grassland, often on granite outcrops, it occasionally develops tendrils.

Branch nodes are conspicuously swollen and new parts of the plant have a ferruginous, floccose covering, persisting on the bracts.

[2] Roots or tubers are powdered or a decoction is prepared and used to treat venereal diseases, naso-pharyngeal infections, fevers and malaria.

[citation needed] The generic name is derived from κισσος or 'kissos', a Greek word for "ivy" - 'cornifolia', having leaves resembling those of Dogwood (Cornus spp.