Civitanova del Sannio is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 25 kilometres (16 mi) northwest of Campobasso and about 15 kilometres (9 mi) northeast of Isernia.

Civitanova del Sannio borders the following municipalities: Bagnoli del Trigno, Chiauci, Duronia, Frosolone, Pescolanciano, Pietrabbondante, Poggio Sannita, Salcito, Sessano del Molise.

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