Macchia d'Isernia is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 40 kilometres (25 mi) west of Campobasso and about 7 kilometres (4 mi) southwest of Isernia.

Macchia d'Isernia borders the following municipalities: Colli a Volturno, Fornelli, Isernia, Monteroduni, Sant'Agapito.

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