Sessano del Molise is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 30 kilometres (19 mi) northwest of Campobasso and about 9 kilometres (6 mi) northeast of Isernia.

As of 31 December 2004, it had a population of 871 and an area of 24.7 square kilometres (9.5 sq mi).

[3] Sessano del Molise borders the following municipalities: Carpinone, Chiauci, Civitanova del Sannio, Frosolone, Miranda, Pesche, Pescolanciano.

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