[5] The Four Seasons Hotel was built on the location of present-day Lincoln Memorial University in 1892 by an English land company, the American Association Limited, which was led locally by flamboyant businessman Alexander Arthur.

During its operation, the Four Seasons Hotel offered buggy rides to nearby English Cave, which had been improved with wooden stairways, walkways, and bridges.

[6] from Claiborne County include State Representative Boyd C. Fugate (1884–1967) and Tennessee's first female sheriff Della Riley.

Claiborne County's musical heritage includes musicians Rodney Atkins, Cindy Morgan and Michael McMeel as well as bluegrass musicians Steve Gulley, Milton Estes, CF Bailey and Shadow Ridge, Vic Graves, Scott and Alan Powers, The Honeycutt Brothers, Buster Turner and the Turner Brothers, Bryan Turner, Patrick Beeler, Larry Carter, Randall Massengill, and Jerry Cole.

Notable Old-Time musicians from Claiborne County include Fiddling Bob Rogers, as well as ballad singers Mae Ray, Alice Parsons, Chester Lewis, and Kinley Brooks, whose repertoires are included in Cecil Sharp's English Folk Songs from the Southern Appalachians.

Other ballad collectors in Claiborne County include Artus Moser, C P Cambiaire, and Tillman Cadle.

Local African American musicians include gospel singers Ralph Ford and Rick Gregory.

Lincoln Memorial University's literary heritage includes authors Silas House, James Still, and Jesse Stuart.

US 25E, established as the East Tennessee Crossing Byway and Appalachian Development Corridor S, provides four-lane expressway north-south access to Grainger County and the Kentucky-Tennessee state-line.