The Clain (French pronunciation: [klɛ̃]; Occitan: Clen) is a 144 km (89 mi) long river in western France, a left tributary of the river Vienne.

The Clain flows generally north, through the following departments and towns: It joins the Vienne near Châtellerault, Cenon-sur-Vienne.

Among its tributaries are the Boivre, the Clouère and the Vonne.

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